Symptoms: lowering blood pressure test phenylpropionate. With orthostatic dysregulation, severe dizziness, headache, fainting, shortness of breath, severe weakness, palpitations, fever, cramps, fatigue, drowsiness. When using high doses – collapse, cyanosis, methemoglobinemia, dyspnea and tachypnea.
Treatment: In case of overdose symptoms immediately put the patient to lift his feet and immediately call a physician.
Interaction with other drugs
The antihypertensive effect of the drug may be excessive in the case of uncontrolled simultaneous reception of vasodilators, antihypertensive agents, phosphodiesterase inhibitors, blockers “slow” calcium channel blockers, tricyclic antidepressants, ethanol, diuretics, beta-blockers, monoamine oxidase inhibitors , procainamide.
Appointment with dihydroergotamine may increase its content in the blood and high blood pressure (due to the increased bioavailability of dihydro-ergotamine). Against the background of quinidine and procainamide may cause orthostatic collapse.
Co-administration of nitroglycerin and heparin reduces the effectiveness of the latter (after discontinuation of the drug may significantly decrease blood clotting, which can demand a reduction of heparin dosage).
Patients undergoing prior treatment with organic nitrates to test phenylpropionate produce the desired hemodynamic effect may require a higher dose. While taking nitroglycerin may also be increased angina with a sharp decrease in blood pressure, ischemia, up to myocardial infarction and sudden death (paradoxical nitrate reaction).
Against the background of Trinitrolong possible a significant reduction in blood pressure and the occurrence of vertigo with a sharp transition to the upright position of “lying” or “sitting”; alcohol consumption, physical exercises and hot weather.
By Trinitrolong, as well as other organic nitrates, with frequent use can develop addictive, does not require increasing the dosage.
If blurred vision or dry mouth persist or are severe, treatment should be discontinued.
When driving vehicles and management mechanisms that require attention, it should be borne in mind that Trinitrolong application may slow down the speed of the motor and mental reactions.
Severity of headache in patients receiving test phenylpropionate can be reduced by reduction of the dose and / or simultaneous reception validol.
If the film swells in the mouth, but does not resolve, this may indicate a expiration date of the drug.